Gynoid lipodystrophy

Gynoid lipodystrophy (or sclerotic fibrous edematous panniculopathy, commonly called "cellulite") is an inflammatory structural disease of the subcutaneous tissue that causes alterations in the skin topography. These changes result from protrusions and depressions of the skin, mainly located in the buttocks, lower limbs, and abdomen.

Cellulite occurs in approximately 90% of adult women. It can begin immediately after puberty, but is more evident in women over 30; men rarely manifest it. The etiopathogenesis of this disease has not yet been identified. Among the various hypotheses there are:

  • Genetic cause. The polymorphism of ACE enzymes (enzymes that convert angiotensin) has been studied for its possible correlation with the onset of cellulite.
  • Hormonal cause. There is evidence showing that estrogens stimulate lipogenesis and inhibit lipolysis.
  • Vascular cause. It has been proposed that a disturbance of the microvascular and lymphatic circulation can, with a staged mechanism, lead to the presence of gynoid lipodystrophy.
  • Morphological cause.The skin depressions can be the result of a tension that the fibrous septae perform downwards, in a direction perpendicular to the surface of the skin, while the protruding areas are the projection of adipose chambers delimited by fibrous septae

The evaluation of cellulite is fundamental both to determine the best treatment and to correctly monitor the results.


One of the techniques used for the treatment of gynoid lipodystrophy is V.L.E.P., as therapies based on the use of radio frequency (M.P.R.F. - R.F.E.P) effectively fight against the cellulite.